Anti-Fibrillin 2 antibody (Internal) (STJ70818)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Fibrillin 2 (Internal) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments gave an approx 30-35kDa band in human placenta lysates after 0.3 µg/ml antibody staining. Please note that currently we cannot find an explanation in the litera |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | FBN2 |
| Gene ID | 2201 |
| Uniprot ID | FBN2_HUMAN |
| Accession Number | NP_001990.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | KELKKLEESNEDDC |
Additional Info
| Post Translational Modifications | Placensin: N-glycosylated. O-glycosylated on serine residues by POGLUT2 and POGLUT3. |
| Function | Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Placensin: Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels. |
| Protein Name | Fibrillin-2 Cleaved Into - Placensin |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-1566948Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedFibrillin-2 And Placensin Chains Are Still Linked Together During The Secretion From CellsBut Are Subsequently Separated By FurinFibrillin-2: SecretedExtracellular SpaceExtracellular MatrixPlacensin: SecretedSecreted By Placental Cells |
| Alternative Antibody Names | Anti-Fibrillin-2 Cleaved Into - Placensin antibodyAnti-FBN2 antibody |
Information sourced from Uniprot.org