Anti-Fibrillin 2 antibody (Internal) (STJ70818)

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STJ70818-100
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Short Description :Goat polyclonal antibody anti-Fibrillin 2 (Internal) is suitable for use in ELISA research applications.
Applications:Pep-ELISA
Host:Goat
Reactivity:Human/Dog/Cow
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:0.5 mg/mL
Purification:Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Dilution Range:Peptide ELISA: antibody detection limit dilution 1:32000.
WB: Preliminary experiments gave an approx 30-35kDa band in human placenta lysates after 0.3 µg/ml antibody staining. Please note that currently we cannot find an explanation in the litera
Formulation:0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Storage Instruction:Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol:FBN2
Gene ID:2201
Uniprot ID:FBN2_HUMAN
Accession Number:NP_001990.2
Immunogen Region:Internal
Immunogen Sequence:KELKKLEESNEDDC
Post Translational Modifications Placensin: N-glycosylated. O-glycosylated on serine residues by POGLUT2 and POGLUT3.
Function Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Placensin: Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels.
Protein Name Fibrillin-2 Cleaved Into - Placensin
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-1566948
Reactome: R-HSA-2129379
Cellular Localisation Secreted
Fibrillin-2 And Placensin Chains Are Still Linked Together During The Secretion From Cells
But Are Subsequently Separated By Furin
Fibrillin-2: Secreted
Extracellular Space
Extracellular Matrix
Placensin: Secreted
Secreted By Placental Cells
Alternative Antibody Names Anti-Fibrillin-2 Cleaved Into - Placensin antibody
Anti-FBN2 antibody

Information sourced from Uniprot.org

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