Anti-FGD5 antibody (STJA0007222)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human FGD5
General Information
| Short Description | Rabbit polyclonal anti-FYVE, RhoGEF and PH domain-containing protein 5 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FGD5 |
| Gene ID | 152273 |
| Uniprot ID | FGD5_HUMAN |
| Immunogen | Synthesized peptide derived from human FGD5 |
| Specificity | This antibody detects endogenous levels of FGD5 at Human, Mouse |
Additional Info
| Function | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. |
| Protein Name | Fyve - Rhogef And Ph Domain-Containing Protein 5Zinc Finger Fyve Domain-Containing Protein 23 |
| Database Links | Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffle MembraneEndoplasmic ReticulumGolgi ApparatusEarly EndosomeIn Peripheral Membrane RufflesColocalizes With F-ActinIn Confluent HuvecsDetected At Cell-Cell-Contact Sites Where It Colocalizes With Vascular Endothelial Cadherin/Cdh5 |
| Alternative Antibody Names | Anti-Fyve - Rhogef And Ph Domain-Containing Protein 5 antibodyAnti-Zinc Finger Fyve Domain-Containing Protein 23 antibodyAnti-FGD5 antibodyAnti-ZFYVE23 antibody |
Information sourced from Uniprot.org