| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FYVE, RhoGEF and PH domain-containing protein 5 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FGD5 |
| Gene ID: |
152273 |
| Uniprot ID: |
FGD5_HUMAN |
| Specificity: |
This antibody detects endogenous levels of FGD5 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human FGD5 |
| Function | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. |
| Protein Name | Fyve - Rhogef And Ph Domain-Containing Protein 5Zinc Finger Fyve Domain-Containing Protein 23 |
| Database Links | Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffle MembraneEndoplasmic ReticulumGolgi ApparatusEarly EndosomeIn Peripheral Membrane RufflesColocolizes With F-ActinIn Confluent HuvecsDetected At Cell-Cell-Contact Sites Where It Colocalizes With Vascular Endothelial Cadherin/Cdh5 |
| Alternative Antibody Names | Anti-Fyve - Rhogef And Ph Domain-Containing Protein 5 antibodyAnti-Zinc Finger Fyve Domain-Containing Protein 23 antibodyAnti-FGD5 antibodyAnti-ZFYVE23 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
