Anti-FERMT2 antibody (STJA0006809)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Kindlin 2
General Information
| Short Description | Rabbit polyclonal anti-Fermitin family homolog 2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FERMT2 |
| Gene ID | 10979 |
| Uniprot ID | FERM2_HUMAN |
| Immunogen | Synthesized peptide derived from human Kindlin 2 |
| Specificity | This antibody detects endogenous levels of Kindlin 2 at Human, Mouse |
Additional Info
| Function | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading.this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. |
| Protein Name | Fermitin Family Homolog 2Kindlin-2Mitogen-Inducible Gene 2 ProteinMig-2Pleckstrin Homology Domain-Containing Family C Member 1Ph Domain-Containing Family C Member 1 |
| Database Links | Reactome: R-HSA-446353Reactome: R-HSA-9013149Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCell CortexCytoskeletonStress FiberCell JunctionFocal AdhesionMembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodium MembraneNucleusMyofibrilSarcomereI BandCell SurfaceColocalizes With Actin Stress Fibers At Cell-Ecm Focal Adhesion SitesColocalizes With Itgb3 At Lamellipodia At The Leading Edge Of Spreading CellsBinds To Membranes That Contain Phosphatidylinositides |
| Alternative Antibody Names | Anti-Fermitin Family Homolog 2 antibodyAnti-Kindlin-2 antibodyAnti-Mitogen-Inducible Gene 2 Protein antibodyAnti-Mig-2 antibodyAnti-Pleckstrin Homology Domain-Containing Family C Member 1 antibodyAnti-Ph Domain-Containing Family C Member 1 antibodyAnti-FERMT2 antibodyAnti-KIND2 antibodyAnti-MIG2 antibodyAnti-PLEKHC1 antibody |
Information sourced from Uniprot.org