| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Fermitin family homolog 2 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FERMT2 |
| Gene ID: |
10979 |
| Uniprot ID: |
FERM2_HUMAN |
| Specificity: |
This antibody detects endogenous levels of Kindlin 2 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human Kindlin 2 |
| Function | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading.this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. |
| Protein Name | Fermitin Family Homolog 2Kindlin-2Mitogen-Inducible Gene 2 ProteinMig-2Pleckstrin Homology Domain-Containing Family C Member 1Ph Domain-Containing Family C Member 1 |
| Database Links | Reactome: R-HSA-446353Reactome: R-HSA-9013149Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCell CortexCytoskeletonStress FiberCell JunctionFocal AdhesionMembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodium MembraneNucleusMyofibrilSarcomereI BandCell SurfaceColocalizes With Actin Stress Fibers At Cell-Ecm Focal Adhesion SitesColocalizes With Itgb3 At Lamellipodia At The Leading Edge Of Spreading CellsBinds To Membranes That Contain Phosphatidylinositides |
| Alternative Antibody Names | Anti-Fermitin Family Homolog 2 antibodyAnti-Kindlin-2 antibodyAnti-Mitogen-Inducible Gene 2 Protein antibodyAnti-Mig-2 antibodyAnti-Pleckstrin Homology Domain-Containing Family C Member 1 antibodyAnti-Ph Domain-Containing Family C Member 1 antibodyAnti-FERMT2 antibodyAnti-KIND2 antibodyAnti-MIG2 antibodyAnti-PLEKHC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
