Anti-FDFT1 antibody (1-260) (STJ27985)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SQS/FDFT1 (1-260) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FDFT1 |
| Gene ID | 2222 |
| Uniprot ID | FDFT_HUMAN |
| Immunogen Region | 1-260 |
| Immunogen Sequence | MEFVKCLGHPEEFYNLVRFR IGGKRKVMPKMDQDSLSSSL KTCYKYLNQTSRSFAAVIQA LDGEMRNAVCIFYLVLRALD TLEDDMTISVEKKVPLLHNF HSFLYQPDWRFMESKEKDRQ VLEDFPTISLEFRNLAEKYQ TVIADICRRMGIGMAEFLDK HVTSEQEWDKYCHYVAGLVG IGLSRLFSASEFEDPLVGED TERANSMGLFLQKTNIIRDY LEDQQGGREFWPQEVWSRY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human SQS/FDFT1 (NP_004453.3). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. |
| Protein Name | Squalene SynthaseSqsSsFpp -Fpp FarnesyltransferaseFarnesyl-Diphosphate FarnesyltransferaseFarnesyl-Diphosphate Farnesyltransferase 1 |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-1989781Reactome: R-HSA-2426168 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Squalene Synthase antibodyAnti-Sqs antibodyAnti-Ss antibodyAnti-Fpp -Fpp Farnesyltransferase antibodyAnti-Farnesyl-Diphosphate Farnesyltransferase antibodyAnti-Farnesyl-Diphosphate Farnesyltransferase 1 antibodyAnti-FDFT1 antibody |
Information sourced from Uniprot.org