| Short Description : | Rabbit monoclonal FBP1 (239-338) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S2MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:6000IF/ICC:1:100-1:400ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FBP1 |
| Gene ID: | 2203 |
| Uniprot ID: | F16P1_HUMAN |
| Immunogen Region: | 239-338 |
| Immunogen Sequence: | APYGARYVGSMVADVHRTLV YGGIFLYPANKKSPNGKLRL LYECNPMAYVMEKAGGMATT GKEAVLDVIPTDIHQRAPVI LGSPDDVLEFLKVYEKHSAQ |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 239-338 of human FBP1 (P09467). |
| Tissue Specificity | Expressed in pancreatic islets. |
| Function | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity.increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. |
| Protein Name | Fructose-1 -6-Bisphosphatase 1Fbpase 1D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 1Liver Fbpase |
| Database Links | Reactome: R-HSA-70263 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Fructose-1 -6-Bisphosphatase 1 antibodyAnti-Fbpase 1 antibodyAnti-D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 1 antibodyAnti-Liver Fbpase antibodyAnti-FBP1 antibodyAnti-FBP antibody |
Information sourced from Uniprot.org
