Anti-FBP1 antibody (239-338) [S2MR] (STJ11101382)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal FBP1 (239-338) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S2MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:6000IF/ICC:1:100-1:400ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FBP1 |
| Gene ID | 2203 |
| Uniprot ID | F16P1_HUMAN |
| Immunogen Region | 239-338 |
| Immunogen Sequence | APYGARYVGSMVADVHRTLV YGGIFLYPANKKSPNGKLRL LYECNPMAYVMEKAGGMATT GKEAVLDVIPTDIHQRAPVI LGSPDDVLEFLKVYEKHSAQ |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 239-338 of human FBP1 (P09467). |
Additional Info
| Tissue Specificity | Expressed in pancreatic islets. |
| Function | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity.increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. |
| Protein Name | Fructose-1 -6-Bisphosphatase 1Fbpase 1D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 1Liver Fbpase |
| Database Links | Reactome: R-HSA-70263 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Fructose-1 -6-Bisphosphatase 1 antibodyAnti-Fbpase 1 antibodyAnti-D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 1 antibodyAnti-Liver Fbpase antibodyAnti-FBP1 antibodyAnti-FBP antibody |
Information sourced from Uniprot.org