Anti-FANCI antibody (STJA0007930)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human FANCI
General Information
| Short Description | Rabbit polyclonal anti-Fanconi anemia group I protein for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FANCI |
| Gene ID | 55215 |
| Uniprot ID | FANCI_HUMAN |
| Immunogen | Synthesized peptide derived from human FANCI |
| Specificity | This antibody detects endogenous levels of FANCI at Human, Mouse |
Additional Info
| Function | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage.this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA. Participates in S phase and G2 phase checkpoint activation upon DNA damage. |
| Protein Name | Fanconi Anemia Group I ProteinProtein Faci |
| Database Links | Reactome: R-HSA-6783310Reactome: R-HSA-6796648 |
| Cellular Localisation | NucleusCytoplasmObserved In Spots Localized In Pairs On The Sister Chromatids Of Mitotic Chromosome Arms And Not CentromeresOne On Each ChromatidsThese Foci Coincide With Common Fragile SitesThey Are Frequently Interlinked Through Blm-Associated Ultra-Fine Dna Bridges |
| Alternative Antibody Names | Anti-Fanconi Anemia Group I Protein antibodyAnti-Protein Faci antibodyAnti-FANCI antibodyAnti-KIAA1794 antibody |
Information sourced from Uniprot.org