| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Fanconi anemia group I protein is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FANCI |
| Gene ID: |
55215 |
| Uniprot ID: |
FANCI_HUMAN |
| Specificity: |
This antibody detects endogenous levels of FANCI at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human FANCI |
| Function | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. |
| Protein Name | Fanconi Anemia Group I ProteinProtein Faci |
| Database Links | Reactome: R-HSA-6783310Reactome: R-HSA-6796648 |
| Cellular Localisation | NucleusCytoplasmObserved In Spots Localized In Pairs On The Sister Chromatids Of Mitotic Chromosome Arms And Not CentromeresOne On Each ChromatidsThese Foci Coincide With Common Fragile SitesThey Are Frequently Interlinked Through Blm-Associated Ultra-Fine Dna Bridges |
| Alternative Antibody Names | Anti-Fanconi Anemia Group I Protein antibodyAnti-Protein Faci antibodyAnti-FANCI antibodyAnti-KIAA1794 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
