| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FAIM3 (18-251) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FCMR |
| Gene ID: |
9214 |
| Uniprot ID: |
FAIM3_HUMAN |
| Immunogen Region: |
18-251 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 18-251 of human FAIM3 (NP_005440.1). |
| Immunogen Sequence: |
RILPEVKVEGELGGSVTIKC PLPEMHVRIYLCREMAGSGT CGTVVSTTNFIKAEYKGRVT LKQYPRKNLFLVEVTQLTES DSGVYACGAGMNTDRGKTQK VTLNVHSEYEPSWEEQPMPE TPKWFHLPYLFQMPAYASSS KFVTRVTTPAQRGKVPPVHH SSPTTQITHRPRVSRASSVA GDKPRTFLPSTTASKISALE GLLKPQTPSYNHHTRLHRQR ALDYGSQSGREGQG |
| Tissue Specificity | Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11.9 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells. |
| Function | May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. |
| Protein Name | Fas Apoptotic Inhibitory Molecule 3Igm Fc Fragment ReceptorRegulator Of Fas-Induced Apoptosis Toso |
| Cellular Localisation | Isoform 1: MembraneSingle-Pass Membrane ProteinIsoform 3: SecretedDetected In The Serum |
| Alternative Antibody Names | Anti-Fas Apoptotic Inhibitory Molecule 3 antibodyAnti-Igm Fc Fragment Receptor antibodyAnti-Regulator Of Fas-Induced Apoptosis Toso antibodyAnti-FCMR antibodyAnti-FAIM3 antibodyAnti-TOSO antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
