| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FCMR |
| Gene ID: |
9214 |
| Uniprot ID: |
FCMR_HUMAN |
| Immunogen Region: |
18-251 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 18-251 of human FAIM3 (NP_005440.1). |
| Immunogen Sequence: |
RILPEVKVEGELGGSVTIKC PLPEMHVRIYLCREMAGSGT CGTVVSTTNFIKAEYKGRVT LKQYPRKNLFLVEVTQLTES DSGVYACGAGMNTDRGKTQK VTLNVHSEYEPSWEEQPMPE TPKWFHLPYLFQMPAYASSS KFVTRVTTPAQRGKVPPVHH SSPTTQITHRPRVSRASSVA GDKPRTFLPSTTASKISALE GLLKPQTPSYNHHTRLHRQR ALDYGSQSGREGQG |
| Tissue Specificity | Expressed by CD19-positive B cells and CD4-positive and CD8-positive T cell populations in primary and secondary lymphoid tissues (at protein level). Among B cell subsets, detected in a subset of bone marrow pro- and pre-B cells, in most follicular and memory B cells and in a small subset of germinal center B cells (at protein level). Expressed at lower levels in CD56-positive NK cells (at protein level). Expressed in lymph nodes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. |
| Post Translational Modifications | Phosphorylated on both Tyr and Ser residues. O-glycosylated. Sialylated. O-linked glycans regulate trafficking to the plasma membrane. |
| Function | High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM. Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues. Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways. |
| Protein Name | Immunoglobulin Mu Fc ReceptorIgm FcrFas Apoptotic Inhibitory Molecule 3Faim3Regulator Of Fas-Induced Apoptosis Toso |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEarly Endosome MembraneGolgi ApparatusTrans-Golgi Network MembraneLysosome MembraneContinuously Recycles Between Cytoplasmic Pool And The Plasma Membrane To Bind As Much Igm As PossibleIsoform 3: SecretedDetected In The Serum |
| Alternative Antibody Names | Anti-Immunoglobulin Mu Fc Receptor antibodyAnti-Igm Fcr antibodyAnti-Fas Apoptotic Inhibitory Molecule 3 antibodyAnti-Faim3 antibodyAnti-Regulator Of Fas-Induced Apoptosis Toso antibodyAnti-FCMR antibodyAnti-FAIM3 antibodyAnti-TOSO antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
