Anti-ESPN antibody (585-854) (STJ118353)

Name: Anti-ESPN antibody (585-854) (STJ118353)
SKU: STJ118353
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ118353

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Short Description	Rabbit polyclonal ESPN (585-854) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	ESPN
Gene ID	83715
Uniprot ID	ESPN_HUMAN
Immunogen Region	585-854
Immunogen Sequence	CAADPKASRELPPPPPPPPP PLPEAASSPPPAPPLPLESA GPGCGQRRSSSSTGSTKSFN MMSPTGDNSELLAEIKAGKS LKPTPQSKGLTTVFSGIGQP AFQPDSPLPSVSPALSPVRS PTPPAAGFQPLLNGSLVPVP PTTPAPGVQLDVEALIPTHD EQGRPIPEWKRQVMVRKMQL KMQEEEEQRRKEEEEEARLA SMPAWRRDLLRKKLEEEREQ KRKEEERQKQEELRREKEQ
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 585-854 of human ESPN (NP_113663.2).

Function	Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation.
Protein Name	Espin Autosomal Recessive Deafness Type 36 Protein Ectoplasmic Specialization Protein
Database Links	Reactome: R-HSA-9662360 Reactome: R-HSA-9662361
Cellular Localisation	Cytoplasm Cytoskeleton Cell Projection Stereocilium Microvillus
Alternative Antibody Names	Anti-Espin antibody Anti-Autosomal Recessive Deafness Type 36 Protein antibody Anti-Ectoplasmic Specialization Protein antibody Anti-ESPN antibody Anti-DFNB36 antibody Anti-LP2654 antibody

Information sourced from Uniprot.org