| Short Description : | Rabbit polyclonal ESPN (585-854) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ESPN |
| Gene ID: | 83715 |
| Uniprot ID: | ESPN_HUMAN |
| Immunogen Region: | 585-854 |
| Immunogen Sequence: | CAADPKASRELPPPPPPPPP PLPEAASSPPPAPPLPLESA GPGCGQRRSSSSTGSTKSFN MMSPTGDNSELLAEIKAGKS LKPTPQSKGLTTVFSGIGQP AFQPDSPLPSVSPALSPVRS PTPPAAGFQPLLNGSLVPVP PTTPAPGVQLDVEALIPTHD EQGRPIPEWKRQVMVRKMQL KMQEEEEQRRKEEEEEARLA SMPAWRRDLLRKKLEEEREQ KRKEEERQKQEELRREKEQ |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 585-854 of human ESPN (NP_113663.2). |
| Function | Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation. |
| Protein Name | EspinAutosomal Recessive Deafness Type 36 ProteinEctoplasmic Specialization Protein |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionStereociliumMicrovillus |
| Alternative Antibody Names | Anti-Espin antibodyAnti-Autosomal Recessive Deafness Type 36 Protein antibodyAnti-Ectoplasmic Specialization Protein antibodyAnti-ESPN antibodyAnti-DFNB36 antibodyAnti-LP2654 antibody |
Information sourced from Uniprot.org
