| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ESPN |
| Gene ID: | 83715 |
| Uniprot ID: | ESPN_HUMAN |
| Immunogen Region: | 585-854 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 585-854 of human ESPN (NP_113663.2). |
| Immunogen Sequence: | CAADPKASRELPPPPPPPPP PLPEAASSPPPAPPLPLESA GPGCGQRRSSSSTGSTKSFN MMSPTGDNSELLAEIKAGKS LKPTPQSKGLTTVFSGIGQP AFQPDSPLPSVSPALSPVRS PTPPAAGFQPLLNGSLVPVP PTTPAPGVQLDVEALIPTHD EQGRPIPEWKRQVMVRKMQL KMQEEEEQRRKEEEEEARLA SMPAWRRDLLRKKLEEEREQ KRKEEERQKQEELRREKEQ |
| Function | Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation. |
| Protein Name | Espin Autosomal Recessive Deafness Type 36 Protein Ectoplasmic Specialization Protein |
| Database Links | Reactome: R-HSA-9662360 Reactome: R-HSA-9662361 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Projection Stereocilium Microvillus |
| Alternative Antibody Names | Anti-Espin antibody Anti-Autosomal Recessive Deafness Type 36 Protein antibody Anti-Ectoplasmic Specialization Protein antibody Anti-ESPN antibody Anti-DFNB36 antibody Anti-LP2654 antibody |
Information sourced from Uniprot.org