Anti-ERLIN2 antibody (239-289 aa) (STJ195613)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ERLN2 at the amino acid range 239-289
General Information
| Short Description | Rabbit polyclonal anti-Erlin-2 (239-289 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ERLIN2 |
| Gene ID | 11160 |
| Uniprot ID | ERLN2_HUMAN |
| Immunogen | Synthesized peptide derived from the human ERLN2 at the amino acid range 239-289 |
| Immunogen Region | 239-289 aa |
| Specificity | This antibody detects endogenous levels of ERLN2 at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | Deubiquitinated by USP25.leading to stabilization. |
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex. |
| Protein Name | Erlin-2Endoplasmic Reticulum Lipid Raft-Associated Protein 2Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2Spfh Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5655302Reactome: R-HSA-5678895Reactome: R-HSA-8853336 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinAssociated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Erlin-2 antibodyAnti-Endoplasmic Reticulum Lipid Raft-Associated Protein 2 antibodyAnti-Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 antibodyAnti-Spfh Domain-Containing Protein 2 antibodyAnti-ERLIN2 antibodyAnti-C8orf2 antibodyAnti-SPFH2 antibodyAnti-UNQ2441 antibodyAnti-PRO5003 antibodyAnti-PRO9924 antibody |
Information sourced from Uniprot.org