| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Erlin-2 (239-289 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ERLIN2 |
| Gene ID: |
11160 |
| Uniprot ID: |
ERLN2_HUMAN |
| Immunogen Region: |
239-289 aa |
| Specificity: |
This antibody detects endogenous levels of ERLN2 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human ERLN2 at the amino acid range 239-289 |
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex. |
| Protein Name | Erlin-2Endoplasmic Reticulum Lipid Raft-Associated Protein 2Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2Spfh Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5655302Reactome: R-HSA-5678895Reactome: R-HSA-8853336 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinAssociated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Erlin-2 antibodyAnti-Endoplasmic Reticulum Lipid Raft-Associated Protein 2 antibodyAnti-Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 antibodyAnti-Spfh Domain-Containing Protein 2 antibodyAnti-ERLIN2 antibodyAnti-C8orf2 antibodyAnti-SPFH2 antibodyAnti-UNQ2441 antibodyAnti-PRO5003 antibodyAnti-PRO9924 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
