| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Erlin-2 (239-289 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ERLIN2 |
| Gene ID: | 11160 |
| Uniprot ID: | ERLN2_HUMAN |
| Immunogen Region: | 239-289 aa |
| Specificity: | This antibody detects endogenous levels of ERLN2 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human ERLN2 at the amino acid range 239-289 |
| Post Translational Modifications | Deubiquitinated by USP25.leading to stabilization. |
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex. |
| Protein Name | Erlin-2 Endoplasmic Reticulum Lipid Raft-Associated Protein 2 Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 Spfh Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-382556 Reactome: R-HSA-5655302 Reactome: R-HSA-5678895 Reactome: R-HSA-8853336 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein Associated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Erlin-2 antibody Anti-Endoplasmic Reticulum Lipid Raft-Associated Protein 2 antibody Anti-Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 antibody Anti-Spfh Domain-Containing Protein 2 antibody Anti-ERLIN2 antibody Anti-C8orf2 antibody Anti-SPFH2 antibody Anti-UNQ2441 antibody Anti-PRO5003 antibody Anti-PRO9924 antibody |
Information sourced from Uniprot.org