Anti-ERCC6L2 antibody (STJA0008974)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ERCC6L2
General Information
| Short Description | Rabbit polyclonal anti-DNA excision repair protein ERCC-6-like 2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ERCC6L2 |
| Gene ID | 375748 |
| Uniprot ID | ER6L2_HUMAN |
| Immunogen | Synthesized peptide derived from human ERCC6L2 |
| Specificity | This antibody detects endogenous levels of ERCC6L2 at Human, Mouse |
Additional Info
| Post Translational Modifications | Phosphorylated by NEK6. |
| Function | Promotes double-strand break (DSB) end-joining and facilitates programmed recombination by controlling how DNA ends are joined in a spatially oriented manner during repair. Also plays a role in DNA repair by restricting DNA end resection in double strand break (DSB) repair. Facilitates replication of complex DNA regions and regulates the maintenance of chromatin structure. |
| Protein Name | Dna Excision Repair Protein Ercc-6-Like 2Dna Repair And Recombination Protein Rad26-LikeExcision Repair Cross-Complementation Group 6-Like 2 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeMitochondrionChromosomeCentromereColocalizes With Nek6 In The CentrosomeIn Response To Dna DamageTranslocates From The Cytosol To Mitochondria And Nucleus In A Reactive Oxygen Species (Ros)-Dependent MannerCentromeric Localization Is Facilitated By Its Interaction With Pcna |
| Alternative Antibody Names | Anti-Dna Excision Repair Protein Ercc-6-Like 2 antibodyAnti-Dna Repair And Recombination Protein Rad26-Like antibodyAnti-Excision Repair Cross-Complementation Group 6-Like 2 antibodyAnti-ERCC6L2 antibodyAnti-C9orf102 antibodyAnti-RAD26L antibody |
Information sourced from Uniprot.org