| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EPS15L1 (475-754) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EPS15L1 |
| Gene ID: |
58513 |
| Uniprot ID: |
EP15R_HUMAN |
| Immunogen Region: |
475-754 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 475-754 of human EPS15L1 (NP_001245304.1). |
| Immunogen Sequence: |
QMISSLKTQIQSQESDLKSQ EDDLNRAKSELNRLQQEETQ LEQSIQAGRVQLETIIKSLK STQDEINQARSKLSQLHESR QEAHRSLEQYDQVLDGAHGA SLTDLANLSEGVSLAERGSF GAMDDPFKNKALLFSNNTQE LHPDPFQTEDPFKSDPFKGA DPFKGDPFQNDPFAEQQTTS TDPFGGDPFKESDPFRGSAT DDFFKKQTKNDPFTSDPFTK NPSLPSKLDPFESSDPFSS |
| Post Translational Modifications | Phosphorylated on tyrosine residues by EGFR. |
| Function | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. |
| Protein Name | Epidermal Growth Factor Receptor Substrate 15-Like 1Eps15-Related ProteinEps15r |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinNucleusMembraneCoated PitLocalized To Plasma Membrane Coated Pits |
| Alternative Antibody Names | Anti-Epidermal Growth Factor Receptor Substrate 15-Like 1 antibodyAnti-Eps15-Related Protein antibodyAnti-Eps15r antibodyAnti-EPS15L1 antibodyAnti-EPS15R antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunohistochemistry analysis of paraffin-embedded human lung cancer using [KO Validated] NBS1/NBS1/NBN Rabbit polyclonal antibody (STJ114898) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/93967/375277/STJ114898_1__01767.1713142004.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded human lung cancer using [KO Validated] NBS1/NBS1/NBN Rabbit polyclonal antibody (STJ114898) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
