| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EPS15L1 |
| Gene ID: | 58513 |
| Uniprot ID: | EP15R_HUMAN |
| Immunogen Region: | 475-754 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 475-754 of human EPS15L1 (NP_001245304.1). |
| Immunogen Sequence: | QMISSLKTQIQSQESDLKSQ EDDLNRAKSELNRLQQEETQ LEQSIQAGRVQLETIIKSLK STQDEINQARSKLSQLHESR QEAHRSLEQYDQVLDGAHGA SLTDLANLSEGVSLAERGSF GAMDDPFKNKALLFSNNTQE LHPDPFQTEDPFKSDPFKGA DPFKGDPFQNDPFAEQQTTS TDPFGGDPFKESDPFRGSAT DDFFKKQTKNDPFTSDPFTK NPSLPSKLDPFESSDPFSS |
| Post Translational Modifications | Phosphorylated on tyrosine residues by EGFR. |
| Function | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. |
| Protein Name | Epidermal Growth Factor Receptor Substrate 15-Like 1Eps15-Related ProteinEps15r |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinNucleusMembraneCoated PitLocalized To Plasma Membrane Coated Pits |
| Alternative Antibody Names | Anti-Epidermal Growth Factor Receptor Substrate 15-Like 1 antibodyAnti-Eps15-Related Protein antibodyAnti-Eps15r antibodyAnti-EPS15L1 antibodyAnti-EPS15R antibody |
Information sourced from Uniprot.org