![Anti-EPHB6 nanobody [SAA1264] (STJN000041)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200654/412836/STJN000041-SDS-PAGE-1__33363.1749232386.jpg?c=1 "Anti-EPHB6 nanobody [SAA1264] (STJN000041)")
![Anti-EPHB6 nanobody [SAA1264] (STJN000041)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200654/412836/STJN000041-SDS-PAGE-1__33363.1749232386.jpg?c=1 "Anti-EPHB6 nanobody [SAA1264] (STJN000041)")
Anti-EPHB6 nanobody [SAA1264] (STJN000041)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Ephrin Type-B Receptor 6 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1264 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | EPHB6 |
| Gene ID | 2051 |
| Uniprot ID | EPHB6_HUMAN |
Additional Info
| Post Translational Modifications | Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion. |
| Function | Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. |
| Protein Name | Ephrin Type-B Receptor 6HepTyrosine-Protein Kinase-Defective Receptor Eph-6 |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928662Reactome: R-HSA-3928664Reactome: R-HSA-3928665 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinIsoform 3: Secreted |
| Alternative Nanobody Names | Anti-Ephrin Type-B Receptor 6 nanobodyAnti-Hep nanobodyAnti-Tyrosine-Protein Kinase-Defective Receptor Eph-6 nanobodyAnti-EPHB6 nanobody |
Information sourced from Uniprot.org