Anti-EPHB6 nanobody [SAA1264] (STJN000041)

Anti-EPHB6 nanobody [SAA1264] (STJN000041)

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STJN000041
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Short Description :Alpaca monoclonal nanobody anti-Ephrin Type-B Receptor 6 is suitable for use in ELISA research applications.
Applications:ELISA
Host:Alpaca
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SAA1264
Isotype:VHH-8His-Cys-tag
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:Purified by Nickel column.
Formulation:0.01M PBS, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol:EPHB6
Gene ID:2051
Uniprot ID:EPHB6_HUMAN
Post Translational Modifications Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
Function Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Protein Name Ephrin Type-B Receptor 6
Hep
Tyrosine-Protein Kinase-Defective Receptor Eph-6
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Isoform 3: Secreted
Alternative Nanobody Names Anti-Ephrin Type-B Receptor 6 nanobody
Anti-Hep nanobody
Anti-Tyrosine-Protein Kinase-Defective Receptor Eph-6 nanobody
Anti-EPHB6 nanobody

Information sourced from Uniprot.org

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