| Post Translational Modifications | Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis.phosphorylation is required for mitotic function. Ubiquitinated at Lys-1034 by UHRF1 via 'Lys-63'-linked ubiquitin chains, leading to interaction with spindle assembly factor TPX2, thereby ensuring accurate distribution to the spindles during metaphase. |
| Function | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface. |
| Protein Name | Kinesin-Like Protein Kif11Kinesin-Like Protein 1Kinesin-Like Spindle Protein HkspKinesin-Related Motor Protein Eg5Thyroid Receptor-Interacting Protein 5Tr-Interacting Protein 5Trip-5 |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-6811434Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmCytoskeletonSpindle Pole |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif11 antibodyAnti-Kinesin-Like Protein 1 antibodyAnti-Kinesin-Like Spindle Protein Hksp antibodyAnti-Kinesin-Related Motor Protein Eg5 antibodyAnti-Thyroid Receptor-Interacting Protein 5 antibodyAnti-Tr-Interacting Protein 5 antibodyAnti-Trip-5 antibodyAnti-KIF11 antibodyAnti-EG5 antibodyAnti-KNSL1 antibodyAnti-TRIP5 antibody |
Information sourced from Uniprot.org
