| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Endothelin receptor type B (31-80 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 100-300WB 1:500-2000ELISA 1:10000-20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EDNRB |
| Gene ID: | 1910 |
| Uniprot ID: | EDNRB_HUMAN |
| Immunogen Region: | 31-80 aa |
| Specificity: | ETBR Polyclonal Antibody detects endogenous levels of ETBR |
| Immunogen: | Synthesized peptide derived from ETBR at the amino acid range 31-80 |
| Post Translational Modifications | Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405. |
| Function | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Name | Endothelin Receptor Type BEt-BEt-BrEndothelin Receptor Non-Selective Type |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-9856649 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalized After Activation By Endothelins |
| Alternative Antibody Names | Anti-Endothelin Receptor Type B antibodyAnti-Et-B antibodyAnti-Et-Br antibodyAnti-Endothelin Receptor Non-Selective Type antibodyAnti-EDNRB antibodyAnti-ETRB antibody |
Information sourced from Uniprot.org
