| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EDAR |
| Gene ID: | 10913 |
| Uniprot ID: | EDAR_HUMAN |
| Immunogen Region: | 27-187 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-187 of human EDAR (NP_071731.1). |
| Immunogen Sequence: | EYSNCGENEYYNQTTGLCQE CPPCGPGEEPYLSCGYGTKD EDYGCVPCPAEKFSKGGYQI CRRHKDCEGFFRATVLTPGD MENDAECGPCLPGYYMLENR PRNIYGMVCYSCLLAPPNTK ECVGATSGASANFPGTSGSS TLSPFQHAHKELSGQGHLAT A |
| Tissue Specificity | Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines. |
| Function | Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member EdarAnhidrotic Ectodysplasin Receptor 1Downless HomologEda-A1 ReceptorEctodermal Dysplasia ReceptorEctodysplasin-A Receptor |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member Edar antibodyAnti-Anhidrotic Ectodysplasin Receptor 1 antibodyAnti-Downless Homolog antibodyAnti-Eda-A1 Receptor antibodyAnti-Ectodermal Dysplasia Receptor antibodyAnti-Ectodysplasin-A Receptor antibodyAnti-EDAR antibodyAnti-DL antibody |
Information sourced from Uniprot.org