Anti-EDAR antibody (27-187) (STJ23468)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal EDAR (27-187) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EDAR |
| Gene ID | 10913 |
| Uniprot ID | EDAR_HUMAN |
| Immunogen Region | 27-187 |
| Immunogen Sequence | EYSNCGENEYYNQTTGLCQE CPPCGPGEEPYLSCGYGTKD EDYGCVPCPAEKFSKGGYQI CRRHKDCEGFFRATVLTPGD MENDAECGPCLPGYYMLENR PRNIYGMVCYSCLLAPPNTK ECVGATSGASANFPGTSGSS TLSPFQHAHKELSGQGHLAT A |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 27-187 of human EDAR (NP_071731.1). |
Additional Info
| Tissue Specificity | Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines. |
| Function | Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member EdarAnhidrotic Ectodysplasin Receptor 1Downless HomologEda-A1 ReceptorEctodermal Dysplasia ReceptorEctodysplasin-A Receptor |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member Edar antibodyAnti-Anhidrotic Ectodysplasin Receptor 1 antibodyAnti-Downless Homolog antibodyAnti-Eda-A1 Receptor antibodyAnti-Ectodermal Dysplasia Receptor antibodyAnti-Ectodysplasin-A Receptor antibodyAnti-EDAR antibodyAnti-DL antibody |
Information sourced from Uniprot.org