| Short Description : | Rabbit polyclonal anti-Ectodysplasin-A (120-170 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EDA |
| Gene ID: | 1896 |
| Uniprot ID: | EDA_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human EDA at the amino acid range 120-170 |
| Immunogen Region: | 120-170 aa |
| Specificity: | EDA Polyclonal Antibody detects endogenous levels of EDA protein. |
| Post Translational Modifications | N-glycosylated. Processing by furin produces a secreted form. |
| Function | Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. May also play a role in cell adhesion. Isoform 1: Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R. Isoform 3: Binds only to the receptor EDA2R. |
| Protein Name | Ectodysplasin-AEctodermal Dysplasia ProteinEda Protein Cleaved Into - Ectodysplasin-A - Membrane Form - Ectodysplasin-A - Secreted Form |
| Database Links | Reactome: R-HSA-5669034 Q92838-3 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinEctodysplasin-ASecreted Form: Secreted |
| Alternative Antibody Names | Anti-Ectodysplasin-A antibodyAnti-Ectodermal Dysplasia Protein antibodyAnti-Eda Protein Cleaved Into - Ectodysplasin-A - Membrane Form - Ectodysplasin-A - Secreted Form antibodyAnti-EDA antibodyAnti-ED1 antibodyAnti-EDA2 antibody |
Information sourced from Uniprot.org
