Anti-E-CADHERIN antibody [MX020] (STJ16101857)

SKU:
STJ16101857-1

€2,103.13
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-E-CADHERIN is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: MX020
Conjugation: Unconjugated
Isotype: IgG
Formulation: Tissue culture supernatant containing 15mM sodium azide
Purification: Concentrate
Dilution Range: IHC-P 1:100-1:200
Storage Instruction: Store at 2-8°C upon receipt.
Background ECAD (syn, CD325) , 120 kDA, chromosome 16q22.1 (CDH1 gene) , is a critical regulator of epithelial junction formation. It interacts with the cytoskeleton through several associated proteins. The ECAD internal domain binds with alpha, beta, gamma and p120 catenin s to anchor the ECAD complex to the actin cytoskeleton of the cell. ECAD is expressed in virtually all epithelial cells except for adrenocortical cells. The expression in liver cells is weaker than in most other epithelia. ECAD is also expressed in melanocytes (adhering to squamous epithelial cells). Pretreatment: Heat induced epitope retrieval in 10 mM citrate buffer, pH6.0 for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections. Note: Dilution of the antibody in 10% normal goat serum followed by a goat anti-mouse secondary antibody-based detection is recommended. Control tissue Pancreas, lung adenocarcinoma, breast. Staining Membranous

Information sourced from Uniprot.org

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