| Host: |
Mouse |
| Applications: |
IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-E-CADHERIN is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
MX020 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Tissue culture supernatant containing 15mM sodium azide |
| Purification: |
Concentrate |
| Dilution Range: |
IHC-P 1:100-1:200 |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Background | ECAD (syn, CD325) , 120 kDA, chromosome 16q22.1 (CDH1 gene) , is a critical regulator of epithelial junction formation. It interacts with the cytoskeleton through several associated proteins. The ECAD internal domain binds with alpha, beta, gamma and p120 catenin s to anchor the ECAD complex to the actin cytoskeleton of the cell. ECAD is expressed in virtually all epithelial cells except for adrenocortical cells. The expression in liver cells is weaker than in most other epithelia. ECAD is also expressed in melanocytes (adhering to squamous epithelial cells). Pretreatment: Heat induced epitope retrieval in 10 mM citrate buffer, pH6.0 for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections. Note: Dilution of the antibody in 10% normal goat serum followed by a goat anti-mouse secondary antibody-based detection is recommended. Control tissue Pancreas, lung adenocarcinoma, breast. Staining Membranous |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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