• Western blot analysis of lysates from K562 cells, using Dysferlin Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-DYSF antibody (1981-2030 aa) (STJ92803)

SKU:
STJ92803

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Dysferlin (1981-2030 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DYSF
Gene ID: 8291
Uniprot ID: DYSF_HUMAN
Immunogen Region: 1981-2030 aa
Specificity: Dysferlin Polyclonal Antibody detects endogenous levels of Dysferlin protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Dysferlin at the amino acid range 1981-2030
Function Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.
Protein Name Dysferlin
Dystrophy-Associated Fer-1-Like Protein
Fer-1-Like Protein 1
Database Links Reactome: R-HSA-445355
Cellular Localisation Cell Membrane
Sarcolemma
Single-Pass Type Ii Membrane Protein
Cytoplasmic Vesicle Membrane
Colocalizes
During Muscle Differentiation
With Bin1 In The T-Tubule System Of Myotubules And At The Site Of Contact Between Two Myotubes Or A Myoblast And A Myotube
Wounding Of Myotubes Led To Its Focal Enrichment To The Site Of Injury And To Its Relocalization In A Ca(2+)-Dependent Manner Toward The Plasma Membrane
Colocalizes With Ahnak
Ahnak2 And Parvb At The Sarcolemma Of Skeletal Muscle
Detected On The Apical Plasma Membrane Of The Syncytiotrophoblast
Reaches The Plasmma Membrane Through A Caveolin-Independent Mechanism
Retained By Caveolin At The Plasmma Membrane
With Cacna1s In The T-Tubule System Of Myotubules
Accumulates And Colocalizes With Fusion Vesicles At The Sarcolemma Disruption Sites
Alternative Antibody Names Anti-Dysferlin antibody
Anti-Dystrophy-Associated Fer-1-Like Protein antibody
Anti-Fer-1-Like Protein 1 antibody
Anti-DYSF antibody
Anti-FER1L1 antibody

Information sourced from Uniprot.org

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