| Host: |
Rabbit |
| Applications: |
WB/IF/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Dysferlin (1981-2030 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DYSF |
| Gene ID: |
8291 |
| Uniprot ID: |
DYSF_HUMAN |
| Immunogen Region: |
1981-2030 aa |
| Specificity: |
Dysferlin Polyclonal Antibody detects endogenous levels of Dysferlin protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human Dysferlin at the amino acid range 1981-2030 |
| Function | Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. |
| Protein Name | DysferlinDystrophy-Associated Fer-1-Like ProteinFer-1-Like Protein 1 |
| Database Links | Reactome: R-HSA-445355 |
| Cellular Localisation | Cell MembraneSarcolemmaSingle-Pass Type Ii Membrane ProteinCytoplasmic Vesicle MembraneColocalizesDuring Muscle DifferentiationWith Bin1 In The T-Tubule System Of Myotubules And At The Site Of Contact Between Two Myotubes Or A Myoblast And A MyotubeWounding Of Myotubes Led To Its Focal Enrichment To The Site Of Injury And To Its Relocalization In A Ca(2+)-Dependent Manner Toward The Plasma MembraneColocalizes With AhnakAhnak2 And Parvb At The Sarcolemma Of Skeletal MuscleDetected On The Apical Plasma Membrane Of The SyncytiotrophoblastReaches The Plasmma Membrane Through A Caveolin-Independent MechanismRetained By Caveolin At The Plasmma MembraneWith Cacna1s In The T-Tubule System Of MyotubulesAccumulates And Colocalizes With Fusion Vesicles At The Sarcolemma Disruption Sites |
| Alternative Antibody Names | Anti-Dysferlin antibodyAnti-Dystrophy-Associated Fer-1-Like Protein antibodyAnti-Fer-1-Like Protein 1 antibodyAnti-DYSF antibodyAnti-FER1L1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
