Anti-DYNC2LI1 antibody (1-352) (STJ26842)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DYNC2LI1 (1-352) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DYNC2LI1 |
| Gene ID | 51626 |
| Uniprot ID | DC2L1_HUMAN |
| Immunogen Region | 1-352 |
| Immunogen Sequence | MPSETLWEIAKAEVEKRGIN GSEGDGAEIAEKFVFFIGSK NGGKTTIILRCLDRDEPPKP TLALEYTYGRRAKGHNTPKD IAHFWELGGGTSLLDLISIP ITGDTLRTFSLVLVLDLSKP NDLWPTMENLLQATKSHVDK VIMKLGKTNAKAVSEMRQKI WNNMPKDHPQDHELIDPFPV PLVIIGSKYDVFQDFESEKR KVICKTLRFVAHYYGASLMF TSKSEALLLKIRGVINQLA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-352 of human DYNC2LI1 (NP_001180393.1). |
Additional Info
| Tissue Specificity | Expressed in bone, brain, kidney, and cartilage. Lower expression in heart, liver, lung, placenta and thymus. |
| Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles. Involved in the regulation of ciliary length. |
| Protein Name | Cytoplasmic Dynein 2 Light Intermediate Chain 1Dynein 2 Light Intermediate Chain |
| Database Links | Reactome: R-HSA-5620924 |
| Cellular Localisation | Golgi ApparatusCytoplasmCell ProjectionCiliumCytoskeletonCilium Basal BodyCilium AxonemeMicrotubule Organizing CenterCentrosomeLocalizes To The Apical Cytoplasm |
| Alternative Antibody Names | Anti-Cytoplasmic Dynein 2 Light Intermediate Chain 1 antibodyAnti-Dynein 2 Light Intermediate Chain antibodyAnti-DYNC2LI1 antibodyAnti-D2LIC antibodyAnti-LIC3 antibodyAnti-CGI-60 antibody |
Information sourced from Uniprot.org