Anti-DUOX2 antibody (STJA0004820)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide of human DUOX2
General Information
| Short Description | Rabbit polyclonal anti-Dual Oxidase 2 for use in IHC and ELISA in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1.56 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:30-1:150 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | DUOX2 |
| Gene ID | 50506 |
| Uniprot ID | DUOX2_HUMAN |
| Immunogen | Synthetic peptide of human DUOX2 |
Additional Info
| Tissue Specificity | Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis. |
| Post Translational Modifications | N-glycosylated. |
| Function | Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. |
| Protein Name | Dual Oxidase 2Large Nox 2Long Nox 2Nadh/Nadph Thyroid Oxidase P138-ToxNadph Oxidase/Peroxidase Duox2Nadph Thyroid Oxidase 2Thyroid Oxidase 2P138 Thyroid Oxidase |
| Database Links | Reactome: R-HSA-209968 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell JunctionLocalizes To The Apical Membrane Of Epithelial CellsLocalizes On Internal Membrane Structures Under Resting ConditionsTranslocates To The Plasma Membrane And Cell-Cell Junctions Upon Challenge With Enteric PathogensSuch As Escherichia Coli |
| Alternative Antibody Names | Anti-Dual Oxidase 2 antibodyAnti-Large Nox 2 antibodyAnti-Long Nox 2 antibodyAnti-Nadh/Nadph Thyroid Oxidase P138-Tox antibodyAnti-Nadph Oxidase/Peroxidase Duox2 antibodyAnti-Nadph Thyroid Oxidase 2 antibodyAnti-Thyroid Oxidase 2 antibodyAnti-P138 Thyroid Oxidase antibodyAnti-DUOX2 antibodyAnti-LNOX2 antibodyAnti-THOX2 antibody |
Information sourced from Uniprot.org