| Host: |
Rabbit |
| Applications: |
IHC/ELISA |
| Reactivity: |
Human/Rat |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Dual Oxidase 2 is suitable for use in Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: |
Antigen affinity purification |
| Concentration: |
1.56 mg/mL |
| Dilution Range: |
IHC 1:30-1:150 |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Tissue Specificity | Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis. |
| Post Translational Modifications | N-glycosylated. |
| Function | Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. |
| Protein Name | Dual Oxidase 2Large Nox 2Long Nox 2Nadh/Nadph Thyroid Oxidase P138-ToxNadph Oxidase/Peroxidase Duox2Nadph Thyroid Oxidase 2Thyroid Oxidase 2P138 Thyroid Oxidase |
| Database Links | Reactome: R-HSA-209968 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell JunctionLocalizes To The Apical Membrane Of Epithelial CellsLocalizes On Internal Membrane Structures Under Resting ConditionsTranslocates To The Plasma Membrane And Cell-Cell Junctions Upon Challenge With Enteric PathogensSuch As Escherichia Coli |
| Alternative Antibody Names | Anti-Dual Oxidase 2 antibodyAnti-Large Nox 2 antibodyAnti-Long Nox 2 antibodyAnti-Nadh/Nadph Thyroid Oxidase P138-Tox antibodyAnti-Nadph Oxidase/Peroxidase Duox2 antibodyAnti-Nadph Thyroid Oxidase 2 antibodyAnti-Thyroid Oxidase 2 antibodyAnti-P138 Thyroid Oxidase antibodyAnti-DUOX2 antibodyAnti-LNOX2 antibodyAnti-THOX2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
