| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Dual oxidase 1 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-Recommended concentration, 4-6µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
DUOX1 |
| Gene ID: |
53905 |
| Uniprot ID: |
DUOX1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_059130.2 ; NP_787954.1 |
| Specificity: |
This antibody is expected to recognise both reported isoforms (NP_059130.2 ; NP_787954.1) which are identical; |
| Immunogen Sequence: |
EKFQRSCLHQTVQ |
| Post Translational Modifications | N-glycosylated. |
| Function | Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. |
| Protein Name | Dual Oxidase 1Large Nox 1Long Nox 1Nadph Thyroid Oxidase 1Thyroid Oxidase 1 |
| Database Links | Reactome: R-HSA-209968 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinLocalizes To The Apical Membrane Of Epithelial Cells |
| Alternative Antibody Names | Anti-Dual Oxidase 1 antibodyAnti-Large Nox 1 antibodyAnti-Long Nox 1 antibodyAnti-Nadph Thyroid Oxidase 1 antibodyAnti-Thyroid Oxidase 1 antibodyAnti-DUOX1 antibodyAnti-DUOX antibodyAnti-LNOX1 antibodyAnti-THOX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
