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![Anti-Double strand DNA antibody [AE-2] (STJ16100690)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149407/302338/STJ16100690_2__86914.1646940535.jpg?c=1 "Anti-Double strand DNA antibody [AE-2] (STJ16100690)")
![Anti-Double strand DNA antibody [AE-2] (STJ16100690)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149407/302337/STJ16100690_1__97580.1646940535.jpg?c=1 "Anti-Double strand DNA antibody [AE-2] (STJ16100690)")
Anti-Double strand DNA antibody [AE-2] (STJ16100690)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG3k
ImmunogenA hybrid (BALB/c x B6) mouse was immunized with nuclei of Raji Burkitt's lymphoma cells.
General Information
| Short Description | Mouse monoclonal anti-Double strand DNA for use in FC, IF and IHC in All Eukaryotes samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/IHC |
| Host | Mouse |
| Reactivity | All Eukaryotes |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AE-2 |
| Isotype | IgG3k |
| Conjugation | Unconjugated |
| Concentration | Can be provided as 100 ยตg/mL, 500 ยตg/mL or 1mg/mL. |
| Purification | Affinity purified from tissue culture. |
| Dilution Range | Flow cytometry (1-2 ยตg/million cells in 0, 1 ml, fix cells in 4% PFA for 10 min, at 4ยฐC, permeabilize with 0, 2% saponin or digitonin for 15 min, at 4ยฐC). Immunofluorescence (1-2 ยตg/ml). Immunohistology (1-2 ยตg/ml for 30 min at RT; staining of formal |
| Formulation | PBS with 0.02% Sodium Azide. |
| Storage Instruction | Store for up to 1 year at 2-8ยฐC upon receipt. |
Target Information
| Gene Symbol | SLC4A2 |
| Gene ID | 6522 |
| Uniprot ID | B3A2_HUMAN |
| Immunogen | A hybrid (BALB/c x B6) mouse was immunized with nuclei of Raji Burkitt's lymphoma cells. |
Additional Info
| Tissue Specificity | Isoform A: Expressed in the liver, stomach, kidney, prostate, thyroid and rectum. Isoform B1: Expressed in the liver and kidney. Isoform B2: Expressed in the liver and kidney. |
| Function | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane. Plays an important role in osteoclast differentiation and function. Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH. Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses. |
| Protein Name | Anion Exchange Protein 2Ae 2Anion Exchanger 2Non-Erythroid Band 3-Like ProteinBnd3lSolute Carrier Family 4 Member 2 |
| Database Links | Reactome: R-HSA-425381 |
| Cellular Localisation | Isoform A: Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneIsoform B1: Apical Cell MembraneIsoform B2: Apical Cell Membrane |
| Alternative Antibody Names | Anti-Anion Exchange Protein 2 antibodyAnti-Ae 2 antibodyAnti-Anion Exchanger 2 antibodyAnti-Non-Erythroid Band 3-Like Protein antibodyAnti-Bnd3l antibodyAnti-Solute Carrier Family 4 Member 2 antibodyAnti-SLC4A2 antibodyAnti-AE2 antibodyAnti-EPB3L1 antibodyAnti-HKB3 antibodyAnti-MPB3L antibody |
Information sourced from Uniprot.org