| Short Description : | Rabbit polyclonal anti-Dedicator of cytokinesis protein 4 (533-583 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DOCK4 |
| Gene ID: | 9732 |
| Uniprot ID: | DOCK4_HUMAN |
| Immunogen: | Synthesized peptide derived from the human DOCK4 at the amino acid range 533-583 |
| Immunogen Region: | 533-583 aa |
| Specificity: | This antibody detects endogenous levels of DOCK4 at Human/Mouse |
| Function | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form. Involved in regulation of adherens junction between cells. Plays a role in cell migration. Isoform 2: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. |
| Protein Name | Dedicator Of Cytokinesis Protein 4 |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-983231 |
| Cellular Localisation | Cell MembraneCell ProjectionCytoplasmCytosolColocalizes With Epha2Rhog And Cttn/Cortactin At The Tip Of Protrusions In Migrating Cells |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 4 antibodyAnti-DOCK4 antibodyAnti-KIAA0716 antibody |
Information sourced from Uniprot.org
