Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:1000-1:5000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | DOCK3 |
Gene ID: | 1795 |
Uniprot ID: | DOCK3_HUMAN |
Immunogen Region: | 1348-1673 aa |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1348-1673 of human DOCK3. (NP_004938.1). |
Immunogen Sequence: | QRLEPEFFRVGFYGRKFPFF LRNKEYVCRGHDYERLEAFQ QRMLSEFPQAVAMQHPNHPD DAILQCDAQYLQIYAVTPIP DYVDVLQMDRVPDRVKSFYR VNNVRKFRYDRPFHKGPKDK ENEFKSLWIERTTLTLTHSL PGISRWFEVERRELVEVSPL ENAIQVVENKNQELRSLISQ YQHKQVHGNINLLSMCLNGV IDAAVNGGIARYQEAFFDKD YINKHPGDAEKITQLKELM |
Tissue Specificity | In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles. |
Function | Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors. |
Protein Name | Dedicator Of Cytokinesis Protein 3 Modifier Of Cell Adhesion Presenilin-Binding Protein Pbp |
Database Links | Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013408 Reactome: R-HSA-9032759 Reactome: R-HSA-983231 |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 3 antibody Anti-Modifier Of Cell Adhesion antibody Anti-Presenilin-Binding Protein antibody Anti-Pbp antibody Anti-DOCK3 antibody Anti-KIAA0299 antibody Anti-MOCA antibody |
Information sourced from Uniprot.org