Anti-DOCK3 antibody (1348-1673 aa) (STJ11105167)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Dedicator Of Cytokinesis Protein 3 (1348-1673 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DOCK3 |
| Gene ID | 1795 |
| Uniprot ID | DOCK3_HUMAN |
| Immunogen Region | 1348-1673 aa |
| Immunogen Sequence | QRLEPEFFRVGFYGRKFPFF LRNKEYVCRGHDYERLEAFQ QRMLSEFPQAVAMQHPNHPD DAILQCDAQYLQIYAVTPIP DYVDVLQMDRVPDRVKSFYR VNNVRKFRYDRPFHKGPKDK ENEFKSLWIERTTLTLTHSL PGISRWFEVERRELVEVSPL ENAIQVVENKNQELRSLISQ YQHKQVHGNINLLSMCLNGV IDAAVNGGIARYQEAFFDKD YINKHPGDAEKITQLKELM |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1348-1673 of human DOCK3. (NP_004938.1). |
Additional Info
| Tissue Specificity | In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles. |
| Function | Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors. |
| Protein Name | Dedicator Of Cytokinesis Protein 3Modifier Of Cell AdhesionPresenilin-Binding ProteinPbp |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9032759Reactome: R-HSA-983231 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 3 antibodyAnti-Modifier Of Cell Adhesion antibodyAnti-Presenilin-Binding Protein antibodyAnti-Pbp antibodyAnti-DOCK3 antibodyAnti-KIAA0299 antibodyAnti-MOCA antibody |
Information sourced from Uniprot.org