Anti-DMPK antibody (11-60 aa) (STJ92728)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human DMPK at the amino acid range 11-60
General Information
| Short Description | Rabbit polyclonal anti-Myotonin-protein kinase (11-60 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DMPK |
| Gene ID | 1760 |
| Uniprot ID | DMPK_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human DMPK at the amino acid range 11-60 |
| Immunogen Region | 11-60 aa |
| Specificity | DMPK Polyclonal Antibody detects endogenous levels of DMPK protein. |
Additional Info
| Post Translational Modifications | Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK. Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity. |
| Function | Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. |
| Protein Name | Myotonin-Protein KinaseMt-PkDm-KinaseDmkDm1 Protein KinaseDmpkMyotonic Dystrophy Protein Kinase |
| Database Links | Reactome: R-HSA-5578775 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinCytoplasmic SideNucleus Outer MembraneMitochondrion Outer MembraneSarcoplasmic Reticulum MembraneCell MembraneCytoplasmCytosolLocalizes To Sarcoplasmic Reticulum Membranes Of CardiomyocytesIsoform 1: Mitochondrion MembraneIsoform 3: Mitochondrion Membrane |
| Alternative Antibody Names | Anti-Myotonin-Protein Kinase antibodyAnti-Mt-Pk antibodyAnti-Dm-Kinase antibodyAnti-Dmk antibodyAnti-Dm1 Protein Kinase antibodyAnti-Dmpk antibodyAnti-Myotonic Dystrophy Protein Kinase antibodyAnti-DMPK antibodyAnti-DM1PK antibodyAnti-MDPK antibody |
Information sourced from Uniprot.org