Anti-DMBT1 antibody (STJ192993)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Deleted in malignant brain tumors 1 protein for use in IHC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-300IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DMBT1 |
| Gene ID | 1755 |
| Uniprot ID | DMBT1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | DMBT1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Highly N- and O-glycosylated. The O-glycans are heavily sulfated. |
| Function | May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. |
| Protein Name | Scavenger Receptor Cysteine-Rich Domain-Containing Protein Dmbt1Deleted In Malignant Brain Tumors 1 ProteinGlycoprotein 340Gp-340HensinSalivary AgglutininSagSurfactant Pulmonary-Associated D-Binding Protein |
| Database Links | Reactome: R-HSA-5683826 |
| Cellular Localisation | SecretedSome Isoforms May Be Membrane-BoundLocalized To The Lumenal Aspect Of Crypt Cells In The Small IntestineIn The ColonSeen In The Lumenal Aspect Of Surface Epithelial CellsFormed In The Ducts Of Von Ebner GlandAnd Released Into The Fluid Bathing The Taste Buds Contained In The Taste Papillae |
| Alternative Antibody Names | Anti-Scavenger Receptor Cysteine-Rich Domain-Containing Protein Dmbt1 antibodyAnti-Deleted In Malignant Brain Tumors 1 Protein antibodyAnti-Glycoprotein 340 antibodyAnti-Gp-340 antibodyAnti-Hensin antibodyAnti-Salivary Agglutinin antibodyAnti-Sag antibodyAnti-Surfactant Pulmonary-Associated D-Binding Protein antibodyAnti-DMBT1 antibodyAnti-GP340 antibody |
Information sourced from Uniprot.org