| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Deleted in malignant brain tumors 1 protein is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-300 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DMBT1 |
| Gene ID: | 1755 |
| Uniprot ID: | DMBT1_HUMAN |
| Specificity: | DMBT1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Highly N- and O-glycosylated. The O-glycans are heavily sulfated. |
| Function | May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. |
| Protein Name | Scavenger Receptor Cysteine-Rich Domain-Containing Protein Dmbt1 Deleted In Malignant Brain Tumors 1 Protein Glycoprotein 340 Gp-340 Hensin Salivary Agglutinin Sag Surfactant Pulmonary-Associated D-Binding Protein |
| Database Links | Reactome: R-HSA-5683826 |
| Cellular Localisation | Secreted Some Isoforms May Be Membrane-Bound Localized To The Lumenal Aspect Of Crypt Cells In The Small Intestine In The Colon Seen In The Lumenal Aspect Of Surface Epithelial Cells Formed In The Ducts Of Von Ebner Gland And Released Into The Fluid Bathing The Taste Buds Contained In The Taste Papillae |
| Alternative Antibody Names | Anti-Scavenger Receptor Cysteine-Rich Domain-Containing Protein Dmbt1 antibody Anti-Deleted In Malignant Brain Tumors 1 Protein antibody Anti-Glycoprotein 340 antibody Anti-Gp-340 antibody Anti-Hensin antibody Anti-Salivary Agglutinin antibody Anti-Sag antibody Anti-Surfactant Pulmonary-Associated D-Binding Protein antibody Anti-DMBT1 antibody Anti-GP340 antibody |
Information sourced from Uniprot.org
