Anti-DLST antibody (C-Term) (STJA0010371)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human C-ternal ODO2
General Information
| Short Description | Rabbit polyclonal anti-Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (C-Term) for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DLST |
| Gene ID | 1743 |
| Uniprot ID | ODO2_HUMAN |
| Immunogen | Synthesized peptide derived from human C-ternal ODO2 |
| Immunogen Region | C-Term |
| Specificity | This antibody detects endogenous levels of ODO2 at Human, Mouse, Rat |
Additional Info
| Function | Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. |
| Protein Name | Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex - Mitochondrial2-Oxoglutarate Dehydrogenase Complex Component E2Ogdc-E2Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase ComplexE2k |
| Database Links | Reactome: R-HSA-6783984Reactome: R-HSA-9853506Reactome: R-HSA-9857492Reactome: R-HSA-9858328 |
| Cellular Localisation | Mitochondrion MatrixNucleusMainly Localizes In The MitochondrionA Small Fraction Localizes To The NucleusWhere The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation |
| Alternative Antibody Names | Anti-Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex - Mitochondrial antibodyAnti-2-Oxoglutarate Dehydrogenase Complex Component E2 antibodyAnti-Ogdc-E2 antibodyAnti-Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex antibodyAnti-E2k antibodyAnti-DLST antibodyAnti-DLTS antibody |
Information sourced from Uniprot.org