| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DLST |
| Gene ID: | 1743 |
| Uniprot ID: | ODO2_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | This antibody detects endogenous levels of ODO2 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human C-ternal ODO2 |
| Function | Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. |
| Protein Name | Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex - Mitochondrial 2-Oxoglutarate Dehydrogenase Complex Component E2 Ogdc-E2 Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex E2k |
| Database Links | Reactome: R-HSA-6783984 Reactome: R-HSA-9853506 Reactome: R-HSA-9857492 Reactome: R-HSA-9858328 |
| Cellular Localisation | Mitochondrion Matrix Nucleus Mainly Localizes In The Mitochondrion A Small Fraction Localizes To The Nucleus Where The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation |
| Alternative Antibody Names | Anti-Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex - Mitochondrial antibody Anti-2-Oxoglutarate Dehydrogenase Complex Component E2 antibody Anti-Ogdc-E2 antibody Anti-Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex antibody Anti-E2k antibody Anti-DLST antibody Anti-DLTS antibody |
Information sourced from Uniprot.org