Immunofluorescence analysis of U-2 OS cells using DLST Rabbit polyclonal antibody (STJ115261) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.

Anti-DLST antibody (1-290) (STJ115261)

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STJ115261
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Applications:WB/IHC-P/IF/ICC/ELISA
Host:Rabbit
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:Lot specific
Purification:Affinity purification
Dilution Range:WB:1:500-1:2000
IHC-P:1:50-1:100
IF/ICC:1:50-1:100
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation:PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:DLST
Gene ID:1743
Uniprot ID:ODO2_HUMAN
Immunogen Region:1-290
Immunogen Sequence:PAKAKPAEAPAAAAPKAEPT AAAVPPPAAPIPTQMPPVPS PSQPPSGKPVSAVKPTVAPP LAEPGAGKGLRSEHREKMNR MRQRIAQRLKEAQNTCAMLT T
Specificity:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human DLST (NP_001924.2).
Function Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
Protein Name Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex - Mitochondrial
2-Oxoglutarate Dehydrogenase Complex Component E2
Ogdc-E2
Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex
E2k
Database Links Reactome: R-HSA-6783984
Reactome: R-HSA-9853506
Reactome: R-HSA-9857492
Reactome: R-HSA-9858328
Cellular Localisation Mitochondrion Matrix
Nucleus
Mainly Localizes In The Mitochondrion
A Small Fraction Localizes To The Nucleus
Where The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation
Alternative Antibody Names Anti-Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex - Mitochondrial antibody
Anti-2-Oxoglutarate Dehydrogenase Complex Component E2 antibody
Anti-Ogdc-E2 antibody
Anti-Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex antibody
Anti-E2k antibody
Anti-DLST antibody
Anti-DLTS antibody

Information sourced from Uniprot.org

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