Anti-DLST antibody (1-290) (STJ115261)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DLST (1-290) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:100IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DLST |
| Gene ID | 1743 |
| Uniprot ID | ODO2_HUMAN |
| Immunogen Region | 1-290 |
| Immunogen Sequence | PAKAKPAEAPAAAAPKAEPT AAAVPPPAAPIPTQMPPVPS PSQPPSGKPVSAVKPTVAPP LAEPGAGKGLRSEHREKMNR MRQRIAQRLKEAQNTCAMLT T |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human DLST (NP_001924.2). |
Additional Info
| Function | Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. |
| Protein Name | Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex - Mitochondrial2-Oxoglutarate Dehydrogenase Complex Component E2Ogdc-E2Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase ComplexE2k |
| Database Links | Reactome: R-HSA-6783984Reactome: R-HSA-9853506Reactome: R-HSA-9857492Reactome: R-HSA-9858328 |
| Cellular Localisation | Mitochondrion MatrixNucleusMainly Localizes In The MitochondrionA Small Fraction Localizes To The NucleusWhere The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation |
| Alternative Antibody Names | Anti-Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex - Mitochondrial antibodyAnti-2-Oxoglutarate Dehydrogenase Complex Component E2 antibodyAnti-Ogdc-E2 antibodyAnti-Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex antibodyAnti-E2k antibodyAnti-DLST antibodyAnti-DLTS antibody |
Information sourced from Uniprot.org