| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DISC1 (1-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DISC1 |
| Gene ID: |
27185 |
| Uniprot ID: |
DISC1_HUMAN |
| Immunogen Region: |
1-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human DISC1 (NP_001158009.1). |
| Immunogen Sequence: |
MPGGGPQGAPAAAGGGGVSH RAGSRDCLPPAACFRRRRLA RRPGYMRSSTGPGIGFLSPA VGTLFRFPGGVSGEESHHSE SRARQCGLDSRGLLVRSPVS KSAAAPTVTSVRGTSAHFGI QLRGGTRLPDRLSWPCGPGS AGWQQEFAAMDSSETLDASW EAACSDGARRVRAAGSLPSA ELSSNSCSPGCGPEVPPTPP |
| Tissue Specificity | Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter. |
| Post Translational Modifications | Ubiquitinated. Ubiquitination with 'Lys-48'-linked polyubiquitin chains leads to its proteasomal degradation. |
| Function | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding. Plays a role, together with PCNT, in the microtubule network formation. |
| Protein Name | Disrupted In Schizophrenia 1 Protein |
| Cellular Localisation | CytoplasmCytoskeletonMitochondrionMicrotubule Organizing CenterCentrosomePostsynaptic DensityColocalizes With Ndel1 In The Perinuclear Region And The CentrosomeLocalizes To Punctate Cytoplasmic Foci Which Overlap In Part With MitochondriaColocalizes With Pcnt At The Centrosome |
| Alternative Antibody Names | Anti-Disrupted In Schizophrenia 1 Protein antibodyAnti-DISC1 antibodyAnti-KIAA0457 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
