Anti-DISC1 antibody (1-200) (STJ27683)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DISC1 (1-200) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DISC1 |
| Gene ID | 27185 |
| Uniprot ID | DISC1_HUMAN |
| Immunogen Region | 1-200 |
| Immunogen Sequence | MPGGGPQGAPAAAGGGGVSH RAGSRDCLPPAACFRRRRLA RRPGYMRSSTGPGIGFLSPA VGTLFRFPGGVSGEESHHSE SRARQCGLDSRGLLVRSPVS KSAAAPTVTSVRGTSAHFGI QLRGGTRLPDRLSWPCGPGS AGWQQEFAAMDSSETLDASW EAACSDGARRVRAAGSLPSA ELSSNSCSPGCGPEVPPTPP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human DISC1 (NP_001158009.1). |
Additional Info
| Tissue Specificity | Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter. |
| Post Translational Modifications | Ubiquitinated. Ubiquitination with 'Lys-48'-linked polyubiquitin chains leads to its proteasomal degradation. |
| Function | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding. Plays a role, together with PCNT, in the microtubule network formation. |
| Protein Name | Disrupted In Schizophrenia 1 Protein |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMitochondrionMicrotubule Organizing CenterCentrosomePostsynaptic DensityColocalizes With Ndel1 In The Perinuclear Region And The CentrosomeLocalizes To Punctate Cytoplasmic Foci Which Overlap In Part With MitochondriaColocalizes With Pcnt At The Centrosome |
| Alternative Antibody Names | Anti-Disrupted In Schizophrenia 1 Protein antibodyAnti-DISC1 antibodyAnti-KIAA0457 antibody |
Information sourced from Uniprot.org