Anti-DHICA Oxidase antibody [R03-6Y2] (STJA0036705)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human TRP1
General Information
| Short Description | Rabbit monoclonal anti-DHICA Oxidase for use in WB, IHC-P and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-6Y2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:50 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TYRP1 |
| Gene ID | 7306 |
| Uniprot ID | TYRP1_HUMAN |
| Immunogen | A synthesized peptide derived from human TRP1 |
Additional Info
| Tissue Specificity | Pigment cells. |
| Post Translational Modifications | Glycosylated. |
| Function | Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. |
| Protein Name | 5 -6-Dihydroxyindole-2-Carboxylic Acid OxidaseDhica OxidaseCatalase BGlycoprotein 75Melanoma Antigen Gp75Tyrosinase-Related Protein 1TrpTrp-1Trp1 |
| Database Links | Reactome: R-HSA-5662702Reactome: R-HSA-9824585 |
| Cellular Localisation | Melanosome MembraneSingle-Pass Type I Membrane ProteinLocated To Mature Stage Iii And Iv Melanosomes And Apposed Endosomal Tubular MembranesTransported To Pigmented Melanosomes By The Bloc-1 ComplexProper Trafficking To Melanosome Is Regulated By Sgsm2Ankrd27Rab9aRab32 And Rab38 |
| Alternative Antibody Names | Anti-5 -6-Dihydroxyindole-2-Carboxylic Acid Oxidase antibodyAnti-Dhica Oxidase antibodyAnti-Catalase B antibodyAnti-Glycoprotein 75 antibodyAnti-Melanoma Antigen Gp75 antibodyAnti-Tyrosinase-Related Protein 1 antibodyAnti-Trp antibodyAnti-Trp-1 antibodyAnti-Trp1 antibodyAnti-TYRP1 antibodyAnti-CAS2 antibodyAnti-TYRP antibodyAnti-TYRRP antibody |
Information sourced from Uniprot.org