| Tissue Specificity | Pigment cells. |
| Post Translational Modifications | Glycosylated. |
| Function | Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. |
| Protein Name | 5 -6-Dihydroxyindole-2-Carboxylic Acid OxidaseDhica OxidaseCatalase BGlycoprotein 75Melanoma Antigen Gp75Tyrosinase-Related Protein 1TrpTrp-1Trp1 |
| Database Links | Reactome: R-HSA-5662702Reactome: R-HSA-9824585 |
| Cellular Localisation | Melanosome MembraneSingle-Pass Type I Membrane ProteinLocated To Mature Stage Iii And Iv Melanosomes And Apposed Endosomal Tubular MembranesTransported To Pigmented Melanosomes By The Bloc-1 ComplexProper Trafficking To Melanosome Is Regulated By Sgsm2Ankrd27Rab9aRab32 And Rab38 |
| Alternative Antibody Names | Anti-5 -6-Dihydroxyindole-2-Carboxylic Acid Oxidase antibodyAnti-Dhica Oxidase antibodyAnti-Catalase B antibodyAnti-Glycoprotein 75 antibodyAnti-Melanoma Antigen Gp75 antibodyAnti-Tyrosinase-Related Protein 1 antibodyAnti-Trp antibodyAnti-Trp-1 antibodyAnti-Trp1 antibodyAnti-TYRP1 antibodyAnti-CAS2 antibodyAnti-TYRP antibodyAnti-TYRRP antibody |
Information sourced from Uniprot.org
